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DPCPX

DPCPX is an adenosine A1 receptor antagonist (Ki = 0.3 nM).<sup class="referenceList">[1]</sup> It is selective for the adenosine A1 receptor over the adenosine A2 receptor (Ki = 340 nM). DPCPX (0.03 and 1 µM) increases the force of contractions in isolated guinea pig left auricles and inhibits decreases in contraction forces induced by the adenosine receptor agonists (–)-N<sup>6</sup>-phenylisopropyladenosine (PIA) or 5'-N-ethylcarboxamidoadenosine (NECA; Item No. 21420) in isolated guinea pig papillary muscles (pA2s = 9.3 and 9, respectively).<sup class="referenceList">[2]</sup> It reverses cardiac arrest induced by adenosine, the adenosine A1 receptor agonist N<sup>6</sup>-cyclopentyladenosine (CPA; Item No. 21448), or the acetylcholine receptor agonist carbachol (carbamoylcholine; Item No. 14486) in isolated rat atrium.<sup class="referenceList">[3]</sup> DPCPX (2 and 4 mg/kg) decreases immobility time in the forced swim test and tail suspension test in mice.<sup class="referenceList">[4]</sup>
102146-07-6
Item No.
TX0007W3
CAS No.
102146-07-6
Molecular Formula
C16H24N4O2
Molecular Weight
304.3874
Pricing ＆ Availability
Pack Size Purity Price(USD) Availability Quantity
5mg 95% $24.00 in stock
10mg ≥98% $26.00 in stock
25mg 95% $49.00 in stock
50mg 98+% $68.00 in stock
100mg 98+% $99.00 in stock
250mg 98+% $245.00 in stock
WARNING This product is for research use only. SDS
Technical Information
Item No.:
TX0007W3
Product Name:
DPCPX
Description:
Synonyms:
8-Cyclopentyl-1,3-dipropylxanthine; 1,3-Dipropyl-8-cyclopentylxanthine; PD 116948; DPCPX
CAS Number:
102146-07-6
MDL:
MFCD00055117
Molecular Formula:
C16H24N4O2
Molecular Weight:
304.3874
SMILES:
O=C(C(N=C(C1CCCC1)N2)=C2N3CCC)N(CCC)C3=O
Animal Administration:
Method(s) not verified, for reference only.
Solubility:
Methanol: Soluble
Shipping Condition:
Room temperature in continental US; may vary elsewhere.
References & Citations:
[1]. 1.Lohse, M.J., Klotz, K.N., Lindenborn-Fotinos, J., et al. 8-Cyclopentyl-1,3-dipropylxanthine (DPCPX) – a selective high affinity antagonist radioligand for A1 adenosine receptors Naunyn Schmiedebergs Arch. Pharmacol. 336(2),204-210 (1987).
[2]. von der Leyen, H., Schmitz, W., Scholz, H., et al. Effects of 1,3-dipropyl-8-cyclopentylxanthine (DPCPX), a highly selective adenosine receptor antagonist, on force of contraction in guinea-pig atrial and ventricular cardiac preparations Naunyn Schmiedebergs Arch. Pharmacol. 340(2),204-209 (1989).
[3]. Camara, H., da Silva, E.D., Jr., Garcia, A.G., et al. Cardiac arrest induced by muscarinic or adenosine receptors agonists is reversed by DPCPX through double mechanism Eur. J. Pharmacol. 819,9-15 (2018).
[4]. Szopa, A., Poleszak, E., Bogatko, K., et al. DPCPX, a selective adenosine A1 receptor antagonist, enhances the antidepressant-like effects of imipramine, escitalopram, and reboxetine in mice behavioral tests Naunyn Schmiedebergs Arch. Pharmacol. 391(12),1361-1371 (2018).