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G protein-coupled Bile Acid Receptor 1

G protein-coupled bile acid receptor 1 (GPCR19, TGR5, GPBAR1) is a plasma membrane-bound, G protein-coupled receptor that has bile acids as its ligand. GPCR19 is a regulator of energy homeostasis, bile acid homeostasis as well as glucose metabolism. GPCR19 transduces extracellular signals through heterotrimeric G proteins.

GPCR19 can be activated by bile acids and then it induces cAMP production. As a membrane receptor, GPCR19 can be internalized into the cytoplasm in response to its ligands. GPCR19 plays important roles in cell signaling pathways such as nuclear factor κB (NF-κB), AKT, and extracellular signal-regulated kinases (ERK). Its agonists may be potential drugs for the treatment of metabolic, inflammation, and digestive disorders. In addition, GPCR19 stimulates glucagon-like peptide 1 (GLP-1) secretion. It also has become an attractive therapeutic target for the prevention and/or the treatment of obesity and its highly associated Type II diabetes and metabolic syndrome.

1000403-03-1
INT-767
CAS No: 1000403-03-1
MW: 494.6601
Purity: 99%
Pricing and Availability
1197300-24-5
4-IsoxazolecarboxaMide, 3-(2-chlorophenyl)-N-(4-chlorophenyl)-N,5-diMethyl-
CAS No: 1197300-24-5
MW: 361.222
Purity: 98%
Pricing and Availability
1198786-98-9
INT-777 R-enantiomer
CAS No: 1198786-98-9
MW: 450.6511
Purity: 98%
Pricing and Availability
1199796-29-6
6α-Ethyl-23(S)-methylcholic acid
CAS No: 1199796-29-6
MW: 450.65113999999994
Purity: 99%
Pricing and Availability
128-13-2
Cholan-24-oic acid, 3,7-dihydroxy-, (3a,5b,7b)-
CAS No: 128-13-2
MW: 392.572
Purity: 98%
Pricing and Availability
1415407-60-1
(4-Cyclopropyl-3,4-dihydro-1(2H)-quinoxalinyl)[4-(2,5-dimethylphenoxy)-3-pyridinyl]methanone
CAS No: 1415407-60-1
MW: 399.4849
Purity: 95%
Pricing and Availability
145224-92-6
Cholan-24-oic acid, 3,12-dihydroxy-, sodium salt, hydrate (1:1:1), (3α,5β,12α)-
CAS No: 145224-92-6
MW: 432.5691
Purity: 95%
Pricing and Availability
1612191-86-2
BAR 502
CAS No: 1612191-86-2
MW: 392.6151
Purity: ≥95%
Pricing and Availability
1632118-69-4
BAR 501
CAS No: 1632118-69-4
MW: 406.6416
Purity: ≥95%
Pricing and Availability
302-95-4
Cholan-24-oic acid, 3,12-dihydroxy-, sodium salt (1:1), (3α,5β,12α)-
CAS No: 302-95-4
MW: 415.56176999999997
Purity: 95%
Pricing and Availability