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E3 Ligase Ligand-Linker Conjugates

E3 Ligase Ligand-Linker Conjugate, which is one part of Proteolysis Targeting Chimeric Molecules (PROTACs), incorporates a ligand for the E3 ubiquitin ligase and a linker. After linked to the ligand for target protein (such as JQ1 for BRD4 protein, Molibresib for BET protein), those conjugates can be used for constituting PROTACs that targetprotein for ubiquitination and degradation. Currently, several PROTACs have been found to show good biological activity by specifically targeting BET, estrogen receptor (ER), androgen receptor, etc. MedChemExpress (MCE) offers a wide range of high quality E3 Ligase Ligand-Linker Conjugates including von Hippel-Lindau (VHL) ligands, MDM2 ligands, Cereblon (CRBN) ligands and cIAP1 ligands conjugating with different linkers (PEGs, Alkyl-Chain, Alkyl/ether, etc.). It’s convenient and time-saving for designing and synthesizinga wide variety of novel PROTACs (ARV-825, dBET1,MT-802, etc.), which can expand the application of PROTACs in the treatment of cancer, autoimmunity, inflammation and other diseases.

1225383-36-7
cIAP1 Ligand-Linker Conjugates 15 hydrochloride
CAS No: 1225383-36-7
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1225433-96-4
cIAP1 Ligand-Linker Conjugates 15
CAS No: 1225433-96-4
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1239866-59-1
cIAP1 Ligand-Linker Conjugates 11 Hydrochloride
CAS No: 1239866-59-1
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1239943-19-1
cIAP1 Ligand-Linker Conjugates 11
CAS No: 1239943-19-1
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1312302-14-9
cIAP1 Ligand-Linker Conjugates 2
CAS No: 1312302-14-9
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1351169-40-8
cIAP1 Ligand-Linker Conjugates 14
CAS No: 1351169-40-8
MW: 719.8205
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1797406-80-4
E3 ligase Ligand-Linker Conjugates 12
CAS No: 1797406-80-4
MW: 645.7701
Purity: 95%
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1797406-81-5
E3 ligase Ligand-Linker Conjugates 4
CAS No: 1797406-81-5
MW: 689.8227
Purity: 95%
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1799506-06-1
HaloPROTAC 2
CAS No: 1799506-06-1
MW: 783.4145
Purity: 99%
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1799711-24-2
N-(4-Aminobutyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide
CAS No: 1799711-24-2
MW: 402.4012
Purity: ≥95%
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