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DYRK

DYRKs (dual-specificity tyrosine-regulated kinases; dual-specificity tyrosine phosphorylation-regulated kinases) comprise a family of protein kinases within the CMGC group of the eukaryotic kinome. DYRKs contain five members in humans that are clustered into two classes based on their phylogenetic relationships: class I DYRKs, DYRK1A and DYRK1B and class II DYRKs, DYRK2, DYRK3, and DYRK4.

DYRK kinases are “dual specificity” kinases, as they can phosphorylate both tyrosine (Y) and serine/threonine (S/T) residues, although Y-phosphorylation is limited to their autophosphorylation activity. DYRK kinases phosphorylate a broad set of substrates that are involved in a wide range of cellular processes, and they are thought to fulfill essential biological functions both during development and in maintaining homeostasis during the adult life. Consequently, the aberrant regulation or expression of DYRK kinases has been associated with several human pathologies, including cancer.

1025821-33-3
(5Z)-2-[(2,6-Dichlorophenyl)amino]-5-(6-quinoxalinylmethylene)-4(5H)-thiazolone
CAS No: 1025821-33-3
MW: 401.2692
Purity: ≥98%
Pricing and Availability
1219795-48-8
4-(Trifluoromethyl)aniline-d4
CAS No: 1219795-48-8
MW: 165.1491
Purity: 99%
Pricing and Availability
1285702-20-6
ML167
CAS No: 1285702-20-6
MW: 335.3566
Purity: ≥98%
Pricing and Availability
1365986-44-2
Protein kinase inhibitors 1
CAS No: 1365986-44-2
MW: 383.4243
Purity: >99%
Pricing and Availability
1386979-55-0
Mirk-IN-1
CAS No: 1386979-55-0
MW: 498.3182
Purity: 99%
Pricing and Availability
1386980-04-6
DYRKs-IN-2
CAS No: 1386980-04-6
MW:
Purity:
Pricing and Availability
1386980-55-7
DYRKs-IN-1 hydrochloride
CAS No: 1386980-55-7
MW: 624.5176
Purity: 95%
Pricing and Availability
1387090-01-8
DYRKs-IN-1
CAS No: 1387090-01-8
MW:
Purity:
Pricing and Availability
147591-46-6
ID 8
CAS No: 147591-46-6
MW: 298.2934
Purity: 98%
Pricing and Availability
1639895-85-4
tBID
CAS No: 1639895-85-4
MW: 528.7764
Purity: 99%
Pricing and Availability