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ADC Cytotoxin

ADC cytotoxins (also known as payloads) are cytotoxic agents that induce target cell death in Antibody Drug Conjugates (ADCs). An ADC is a targeted agent composed with a monoclonal antibody, a linker and a cytotoxin. The cytotoxin is the most important component as it determines the potency to kill cancer cells of an ADC.

There are many cytotoxins which are currently being used such as Calicheamicins, Duocarmycins, Pyrrolobenzodiazepines (PBDs), Camptothecins, Daunorubicins/Doxorubicins, Auristatins and Maytansinoids. They can be divided in two classes based on their mechanism of action, DNA damaging agents and tubulin inhibitors. Among them Calicheamicins, Duocarmycins and PBDs are DNA minor grove binders, Camptothecins and Daunorubicins/Doxorubicins are topoisomerase inhibitors, which are DNA damaging agents. Auristatins and Maytansinoids are tubulin inhibitors. Except for the listed cytotoxins, there are numbers of traditional cytotoxic agents with similar mechanisms of killing cancer cells and can also be used in the development of ADCs.

100940-65-6
Sandramycin
CAS No: 100940-65-6
MW: 1221.3162
Purity: ≥95%
Pricing and Availability
1032072-50-6
Tubulysin IM-2
CAS No: 1032072-50-6
MW: 538.6999
Purity:
Pricing and Availability
105049-15-8
Mytoxin B
CAS No: 105049-15-8
MW: 528.5907
Purity:
Pricing and Availability
108212-75-5
calicheamicin gamma(1)I
CAS No: 108212-75-5
MW:
Purity: ≥95%
Pricing and Availability
110417-88-4
Dolastatin 10
CAS No: 110417-88-4
MW: 785.0909
Purity: 95%
Pricing and Availability
1116745-06-2
Duocarmycin DM
CAS No: 1116745-06-2
MW: 463.9559
Purity: 99%
Pricing and Availability
1146534-45-3
Aminohexylgeldanamycin hydrochloride
CAS No: 1146534-45-3
MW:
Purity:
Pricing and Availability
118292-34-5
Duocarmycin A
CAS No: 118292-34-5
MW: 507.492
Purity:
Pricing and Availability
1204819-92-0
PNU-159682 CARBOXYLIC ACID
CAS No: 1204819-92-0
MW: 627.5926
Purity: 92%
Pricing and Availability
1222490-34-7
5H-Pyrrolo[2,1-c][1,4]benzodiazepin-5-one, 2-(4-aminophenyl)-8-[3-[[(11aS)-5,11a-dihydro-7-methoxy-2-(4-methoxyphenyl)-5-oxo-1H-pyrrolo[2,1-c][1,4]benzodiazepin-8-yl]oxy]propoxy]-1,11a-dihydro-7-methoxy-, (11aS)-
CAS No: 1222490-34-7
MW: 725.7884
Purity: 98%
Pricing and Availability