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AEM1

Cancer cell survival appears partly dependent on antioxidative enzymes, whose expression is regulated by the Keap1-Nrf2 pathway, to quench potentially toxic reactive oxygen species generated by their metastatic transformation.<sup class="referenceList">[1]</sup> AEM1 is an inhibitor of gene expression induced by nuclear erythroid 2-related factor 2 (Nrf2).<sup class="referenceList">[2]</sup> It reduces Nrf2-dependent expression of the genes encoding superoxide dismutase 1 (SOD1), heme oxygenase 1 (HO-1), thioredoxin (Trx), glutamate-cysteine ligase (GCLM), and glutathione peroxidase 2 (GPX2), as well as decreases glutathione (GSH) content in A549 cells when used at 5 µM. AEM1 enhances tert-butyl hydroperoxide-induced A549 cell death. In vivo, AEM1 (50 mg/kg) reduces tumor volume in an A549 mouse xenograft model.
1030123-90-0
Item No.
TX01C2BY
CAS No.
1030123-90-0
Molecular Formula
C20H14FN3O2S
Molecular Weight
379.4075
Pricing ＆ Availability
Pack Size Purity Price(USD) Availability Quantity
2mg 95% $24.00 in stock
5mg 95% $36.00 in stock
10mg 95% $63.00 in stock
25mg 95% $134.00 in stock
50mg 95% $235.00 in stock
100mg 95% $403.00 in stock
200mg 95% $582.00 in stock
WARNING This product is for research use only. SDS
Technical Information
Item No.:
TX01C2BY
Product Name:
AEM1
Description:
Synonyms:
AEM1
CAS Number:
1030123-90-0
MDL:
MFCD15017488
Molecular Formula:
C20H14FN3O2S
Molecular Weight:
379.4075
SMILES:
FC(C=C1)=CC=C1C2=CSC3=C2C(NCC4=CC=C(OCO5)C5=C4)=NC=N3
λmax:
283 nm
Solubility:
DMF: 30 mg/mL, DMF:PBS (pH 7.2) (1:4): 0.2 mg/mL, DMSO: 20 mg/mL, Ethanol: 0.25 mg/mL
Shipping Condition:
Room temperature in continental US; may vary elsewhere.
References & Citations:
[1]. 1.DeNicola, G.M., Karreth, F.A., Humpton, T.J., et al. Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis Nature 475(7354),106-109 (2011).
[2]. Bollong, M.J., Yun, H., Sherwood, L., et al. A small molecule inhibits deregulated NRF2 transcriptional activity in cancer ACS Chem. Biol. 10(10),2193-2198 (2015).