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Ligands for E3 Ligase

A PROTAC (Proteolysis Targeting Chimeric Molecule) is a protein degrader comprised of a ligand for E3 ligase (E3 ligase binder), a linker and a ligand for target protein (target binder). The association between an E3 ligase and a target protein induced by a PROTAC will lead to the transfer of ubiquitin and degradation of the targeted protein.

E3 ligases catalyze the transfer of ubiquitin to targeted proteins and determine the specificity of the proteins. There are hundreds of E3 ligases in cells, but only a limited number of them are successfully used in reported PROTACs, such as VHL (von Hippel-Lindau disease tumor suppressor protein), CRBN (Cereblon), MDM2 (the mouse double minute 2 homologue) and IAP (inhibitor of apoptosis).

1010100-07-8
N-(3-chloro-4-methylphenyl)-N'-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1-oxo-1H-isoindol-5-yl]methyl]-urea
CAS No: 1010100-07-8
MW: 440.8795
Purity:
Pricing and Availability
1010100-26-1
3-(5-Bromo-1-oxoisoindolin-2-yl)piperidine-2,6-dione
CAS No: 1010100-26-1
MW: 323.1420
Purity: 98%
Pricing and Availability
1010100-28-3
3-(5-(Aminomethyl)-1-oxoisoindolin-2-yl)pipe ridine-2,6-dione
CAS No: 1010100-28-3
MW: 273.2872
Purity:
Pricing and Availability
1061604-41-8
3-(4-hydroxy-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione
CAS No: 1061604-41-8
MW: 260.2454
Purity: 97%
Pricing and Availability
1061605-21-7
2-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]aceticacid
CAS No: 1061605-21-7
MW: 332.2650
Purity: 95%
Pricing and Availability
1073560-68-5
(S)-2-((S)-1-((S)-2-((S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)propanamido)-2-cyclohexylacetyl)pyrrolidine-2-carboxamido)-3,3-diphenylpropanoicacid
CAS No: 1073560-68-5
MW: 784.9384
Purity: 97%
Pricing and Availability
1158264-69-7
3-[5-(aminomethyl)-1-oxo-2,3-dihydro-1H-isoindol-2-yl]piperidine-2,6-dione hydrochloride
CAS No: 1158264-69-7
MW: 309.7481
Purity: 98%
Pricing and Availability
1219177-18-0
Thalidomide-d4
CAS No: 1219177-18-0
MW: 262.2541
Purity: ≥99% deuterated forms (d1-d4)
Pricing and Availability
1225383-33-4
E3 ligase Ligand 8
CAS No: 1225383-33-4
MW: 530.6115
Purity: 95%
Pricing and Availability
1282513-77-2
β-Naphthoflavone-CH2-Br
CAS No: 1282513-77-2
MW: 365.2200
Purity:
Pricing and Availability