ML-9

Name: Name:ML-9 HYDROCHLORIDE
Brand: 10X CHEM
SKU: TX008SJR
Availability: InStock
Rating: 100 (1 reviews)

ML-9 was originally identified as a selective Ca2+-calmodulin-dependent myosin light chain kinase inhibitor. Concentrations from 10-100 µM are effective at inhibiting vascular smooth muscle tension and reducing intracellular Ca2+ concentrations.[1] ML-9 also inhibits PKB/Akt activity with an IC50 range of 10-50 µM in rat primary adipocytes. This results in a specific inhibition of insulin-stimulated glucose transport and GLUT4/IGF II receptor translocation to the plasma membrane yet does not interfere with the antilipolytic effect of insulin.[2] Additionally, ML-9 inhibits other serine/threonine kinases including PKA (IC50 = ~20 µM), p90 S6 (IC50 = ~50 µM), and MAP kinase (IC50 = ~35 µM).[2]

Item No.

TX008SJR

CAS No.

105637-50-1

Molecular Formula

C15H18Cl2N2O2S

Molecular Weight

361.2866

Pricing ＆ Availability

Pack Size	Purity	Price(USD)	Availability
1mg	99%	$11.00	in stock
5mg	95%	$26.00	in stock
10mg	95%	$39.00	in stock
25mg	95%	$73.00	in stock
50mg	95%	$119.00	in stock
100mg	95%	$177.00	in stock
250mg	95%	$439.00	in stock
1g	95%	$874.00	in stock

WARNING This product is for research use only.

SDS

Technical Information

Item No.:

TX008SJR

Product Name:

ML-9

Description:

Synonyms:

ML-9

CAS Number:

105637-50-1

MDL:

MFCD00065525

Molecular Formula:

C15H18Cl2N2O2S

Molecular Weight:

361.2866

SMILES:

ClC1=CC=CC2=C1C=CC=C2S(=O)(N3CCCN([H])CC3)=O.Cl

λmax:

229, 300 nm

Solubility:

DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2)(1:1): 0.5 mg/ml, Ethanol: 0.5 mg/ml

Shipping Condition:

Room temperature in continental US; may vary elsewhere.

References & Citations:

[1]. 1.Ito, S., Kume, H., Honjo, H., et al. ML-9, a myosin light chain kinase inhibitor, reduces intracellular Ca2+ concentration in guinea pig trachealis Eur. J. Pharmacol. 486,325-333 (2004).

[2]. Smith, U., Carvalho, E., Mosialou, E., et al. PKB inhibition prevents the stimulatory effect of insulin on glucose transport and protein translocation but not the antilipolytic effect in rat adipocytes Biochem. Biophys. Res. Commun. 268,315-320 (2000).