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IWR-1-exo

Wnt signaling proteins are small secreted proteins that are active in embryonic development, tissue homeostasis,<sup class="referenceList">[1]</sup> and tumorigenesis.<sup class="referenceList">[2],[3]</sup> Wnt proteins bind to receptors on the cell surface, initiating a signaling cascade that leads to β-catenin activation of gene transcription. IWR-1-exo is a diastereomer of IWR-1-endo, the potent inhibitor of the Wnt response.<sup class="referenceList">[4]</sup> Whereas IWR-1-endo strongly blocks cell-based Wnt/β-catenin pathway reporter response (IC50 = 180 nM)<sup class="referenceList">[4]</sup> and suppresses Wnt-dependent zebrafish tail fin regeneration (0.5 μM),<sup class="referenceList">[5]</sup> IWR-1-exo has little effect in either assay at 10 μM.<sup class="referenceList">[4]</sup> Thus, this compound is an ideal control for tests involving the active form, IWR-1-endo.
1127442-87-8
Item No.
TX008TXM
CAS No.
1127442-87-8
Molecular Formula
C25H19N3O3
Molecular Weight
409.43666
Pricing ＆ Availability
Pack Size Purity Price(USD) Availability Quantity
5mg 95% $22.00 in stock
10mg 95% $36.00 in stock
25mg 95% $81.00 in stock
50mg 95% $138.00 in stock
100mg 95% $221.00 in stock
200mg 95% $321.00 in stock
WARNING This product is for research use only. SDS
Technical Information
Item No.:
TX008TXM
Product Name:
IWR-1-exo
Description:
Synonyms:
IWR-1-exo; exo-IWR-1
CAS Number:
1127442-87-8
MDL:
MFCD18086912
Molecular Formula:
C25H19N3O3
Molecular Weight:
409.43666
SMILES:
[H][C@]12[C@](C(N(C3=CC=C(C(NC4=CC=CC5=C4N=CC=C5)=O)C=C3)C2=O)=O)([H])[C@@H]6C=C[C@H]1C6
λmax:
202, 241, 320 nm
Solubility:
Chloroform: 1 mg/ml, DMF: 5 mg/ml, DMF:PBS (pH 7.2)(1:3): 0.25 mg/ml, DMSO: 0.3 mg/ml
Shipping Condition:
Room temperature in continental US; may vary elsewhere.
References & Citations:
[1]. 1.Reya, T., and Clevers, H. Wnt signalling in stem cells and cancer Nature 434(7035),834-850 (2005).
[2]. Polakis, P. Wnt signaling and cancer Genes Dev. 14(15),1837-1851 (2000).
[3]. Chen, B., Dodge, M.E., Tang, W., et al. Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer Nat. Chem. Biol. 5(2),100-107 (2009).
[4]. Clevers, H. Wnt/β-catenin signaling in development and disease Cell 127(3),469-480 (2006).
[5]. Lu, J., Ma, Z., Hsieh, J.C., et al. Structure-activity relationship studies of small-molecule inhibitors of Wnt response Bioorg. Med. Chem. Lett. 19(14),3825-3827 (2009).