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SAR-020106

SAR-020106 is an ATP-competitive, potent, and selective CHK1 inhibitor with an IC50 of 13.3 nM for human CHK1. SAR-020106 shows excellent selectivity over CHK2. SAR-020106 significantly enhances the cell killing of Gemcitabine and SN38 by 3- to 29-fold in several colon tumor lines and in a p53-dependent fashion. SAR-020106 can enhance antitumor activity with selected anticancer agents[1][2].
1184843-57-9
Item No.
TX00910B
CAS No.
1184843-57-9
Molecular Formula
C19H19ClN6O
Molecular Weight
382.8468
Pricing ＆ Availability
Pack Size Purity Price(USD) Availability Quantity
1mg 95% $33.00 in stock
5mg 98% $64.00 in stock
10mg 98% $82.00 in stock
25mg 98% $164.00 in stock
100mg 95% $588.00 in stock
WARNING This product is for research use only. SDS
Technical Information
Item No.:
TX00910B
Product Name:
SAR-020106
Description:
Synonyms:
SAR-020106
CAS Number:
1184843-57-9
MDL:
MFCD28155090
Molecular Formula:
C19H19ClN6O
Molecular Weight:
382.8468
SMILES:
C[C@H](CN(C)C)OC1=NC(NC2=NC=C3C(Cl)=CC=CC3=C2)=CN=C1C#N
IC₅₀ & Target:
Chk1
13.3 nM (IC50)
Shipping Condition:
Room temperature in continental US; may vary elsewhere.
References & Citations:
[1]. Walton MI, et al. The preclinical pharmacology and therapeutic activity of the novel CHK1 inhibitor SAR-020106. Mol Cancer Ther. 2010;9(1):89-100.
[2]. Reader JC, et al. Structure-guided evolution of potent and selective CHK1 inhibitors through scaffold morphing. J Med Chem. 2011;54(24):8328-8342.  .