Leukotriene E4-d5 MaxSpec® Standard

Name: Name:Leukotriene E4-d5
Brand: 10X CHEM
SKU: TX009CU4
Rating: 98 (1 reviews)

Leukotriene E4-d5 (LTE4-d5) is intended for use as an internal standard for the quantification of LTE4 by GC- or LC-mass spectrometry. LTE4 is produced by the action of dipeptidase on LTD4, leaving only the cysteinyl group still attached to the fatty acid backbone.[1] It is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A).[2] LTE4 is considerably less active (8 to 12-fold) than LTC4 in the biological activities characteristic of cysteinyl leukotrienes.[1],[3] Unlike LTC4 and LTD4, LTE4 accumulates in both plasma and urine. Therefore, urinary excretion of LTE4 is most often used as an indicator of asthma.[4],[5],[6] In humans, basal levels of LTE4 range from 1-100 pg/mg creatinine. In asthmatic patients, urinary LTE4 levels increase to 80-1,000 pg/mg creatinine.[5] LTE4-d5 MaxSpec® standard is a quantitative grade standard of LTE4-d5 that has been prepared specifically for mass spectrometry or any application where quantitative reproducibility is required. The solution has been prepared gravimetrically and is supplied in a deactivated glass ampule sealed under argon. The concentration was verified by comparison to an independently prepared calibration standard. This LTE4-d5 MaxSpec® standard is guaranteed to meet identity, purity, stability, and concentration specifications and is provided with a batch-specific certificate of analysis. Ongoing stability testing is performed to ensure the concentration remains accurate throughout the shelf life of the product. Note: The amount of solution added to the vial is in excess of the listed amount. Therefore, it is necessary to accurately measure volumes for preparation of calibration standards. Follow recommended storage and handling conditions to maintain product quality.

Item No.

TX009CU4

CAS No.

1240398-14-4

Molecular Formula

C23H32D5NO5S

Molecular Weight

444.6394

Pricing ＆ Availability

Pack Size	Purity	Price(USD)	Availability	Quantity
Request Quote

WARNING This product is for research use only.

SDS

Technical Information

Item No.:

TX009CU4

Product Name:

Leukotriene E4-d5 MaxSpec® Standard

Description:

Synonyms:

LTE4-d5; Leukotriene E4-d5 MaxSpec® Standard; Leukotriene E4-d5

CAS Number:

1240398-14-4

MDL:

MFCD10567081

Molecular Formula:

C23H32D5NO5S

Molecular Weight:

444.6394

SMILES:

O[C@@H](CCCC(O)=O)[C@H](SC[C@H](N)C(O)=O)/C=C/C=C/C=C\C/C=C\CCCC([2H])([2H])C([2H])([2H])[2H]

Shipping Condition:

Room temperature in continental US; may vary elsewhere.

References & Citations:

[1]. 1.Samuelsson, B. Leukotrienes: Mediators of immediate hypersensitivity reactions and inflammation Science 220(4597),568-575 (1983).

[2]. Lefer, A.M. Leukotrienes as mediators of ischemia and shock Biochem. Pharmacol. 35(2),123-127 (1986).

[3]. Drazen, J.M., O'Brien, J., Sparrow, D., et al. Recovery of leukotriene E4 from the urine of patients with airway obstruction Am. Rev. Respir. Dis. 146(1),104-108 (1992).

[4]. Kumlin, M., Stensvad, F., Larsson, L., et al. Validation and application of a new simple strategy for measurements of urinary leukotriene E4 in humans Clin. Exp. Allergy 25(5),467-479 (1995).

[5]. Kumlin, M., Dahlén, B., Björck, T., et al. Urinary excretion of leukotriene E4 and 11-dehydro-thromboxane B2 in response to bronchial provocations with allergen, aspirin, leukotriene D4, and histamine in asthmatics Am. Rev. Respir. Dis. 146(1),96-103 (1992).

[6]. Bernström, K., and Hammarström, S. Metabolism of leukotriene D by porcine kidney J. Biol. Chem. 256(18),9579-9582 (1981).