Login

Dydrogesterone

Dydrogesterone is a synthetic progestogen that has no estrogenic, androgenic, glucocorticoid, or anabolic effects, although it is an agonist of progesterone receptors (EC50 = 12.3 nM) and an antagonist of androgen, mineralocorticoid, and glucocorticoid receptors (IC50s = 28.6, 82.7, and 363 nM, respectively).<sup class="referenceList">[1],[2]</sup> Dydrogesterone protects against sound stress-induced abortion in mice when administered at a dose of 1.25 mg per animal prior to the stressor on day five of pregnancy.<sup class="referenceList">[3]</sup> Formulations containing dydrogesterone have been used in hormone replacement therapy, in the treatment of menstrual disorders, and to prevent miscarriage.
152-62-5
Item No.
TX007KJO
CAS No.
152-62-5
Molecular Formula
C21H28O2
Molecular Weight
312.4458
Pricing ＆ Availability
Pack Size Purity Price(USD) Availability Quantity
1mg 95% $24.00 in stock
10mg ≥98% $42.00 in stock
25mg ≥98% $98.00 in stock
50mg ≥98% $184.00 in stock
100mg 97% $332.00 in stock
200mg $430.00 in stock
WARNING This product is for research use only. SDS
Technical Information
Item No.:
TX007KJO
Product Name:
Dydrogesterone
Description:
Synonyms:
NSC 92336; Dydrogesterone
CAS Number:
152-62-5
MDL:
MFCD00867864
Molecular Formula:
C21H28O2
Molecular Weight:
312.4458
SMILES:
CC([C@]1CC[C@@]2([H])[C@]3([H])C=CC4=CC(CC[C@@]4(C)[C@]3([H])CC[C@]12C)=O)=O
λmax:
287 nm
In Vitro:
Dydrogesterone is a potent, orally active progestogen indicated in a wide variety of gynaecological conditions related to progesterone deficiency. Although similar in molecular structure and pharmacological effects to endogenous progesterone. It is orally active at far lower doses. Its freedom from estrogenic, androgenic, anabolic, corticoid and other undesirable hormonal effects gives it additional benefits over most other synthetic progestogens.Dydrogesterone has also been registered as hormone replacement therapy (HRT) to counteract the negative effects of unopposed estrogen on the endometrium in women with an intact uterus. Dydrogesterone is relatively safe and well tolerated, and does not exhibit the androgenic side effects that are common with some other progestins, like medroxyprogesterone. Method(s) not verified, for reference only.
Solubility:
Acetonitrile: 1 mg/ml, Ethanol: 1 mg/ml, Methanol: 1 mg/ml
Shipping Condition:
Room temperature in continental US; may vary elsewhere.
References & Citations:
[1]. 1.Coelingh Bennink, H.J., and Boerrigter, P.J. Use of dydrogesterone as a progestogen for oral contraception Steroids 68(10-13),927-929 (2003).
[2]. Rižner, T.L., Brožič, P., Doucette, C., et al. Selectivity and potency of the retroprogesterone dydrogesterone in vitro Steroids 76(6),607-615 (2011).
[3]. Joachim, R., Zenclussen, A.C., Polgar, B., et al. The progesterone derivative dydrogesterone abrogates murine stress-triggered abortion by inducing a Th2 biased local immune response Steroids 68(10-13),931-940 (2003).