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Erucin

Erucin is an isothiocyanate derived from glucoerucin, a glucosinolate predominant in arugula (Eruca sativa Mill.) and other cruciferous vegetables. At 2.5-5 μM erucin can induce significant neuroprotective and antioxidant effects, increasing both total glutathione levels and total antioxidant capacity at the cytosolic level in dopaminergic-like neuroblastoma SH-SY5Y cells.<sup class="referenceList">[1]</sup> Growth inhibition, cell cycle regulation, apoptosis, and induction of detoxification enzymes have all been reported from use of erucin in prostate, lung, liver, and colon cancer cells.<sup class="referenceList">[2],[3]</sup>
4430-36-8
Item No.
TX00DGH0
CAS No.
4430-36-8
Molecular Formula
C6H11NS2
Molecular Weight
161.2882
Pricing ＆ Availability
Pack Size Purity Price(USD) Availability Quantity
10mg ≥98% $53.00 in stock
25mg ≥98% $102.00 in stock
50mg >98.0%(GC) $126.00 in stock
250mg >98.0%(GC) $375.00 in stock
WARNING This product is for research use only. SDS
Technical Information
Item No.:
TX00DGH0
Product Name:
Erucin
Description:
Synonyms:
Erucin
CAS Number:
4430-36-8
MDL:
MFCD1656048
Molecular Formula:
C6H11NS2
Molecular Weight:
161.2882
SMILES:
CSCCCCN=C=S
λmax:
244 nm
Solubility:
DMF: 12 mg/ml, DMSO: 14 mg/ml, Ethanol: 16 mg/ml, Ethanol:PBS (pH7.2)(1:50): 0.02 mg/ml
Shipping Condition:
Room temperature in continental US; may vary elsewhere.
References & Citations:
[1]. 1.Zhang, Y., Talalay, P., Cho, C.G., et al. A major inducer of anticarcinogenic protective enzymes from broccoli: Isolation and elucidation of structure Proc. Natl. Acad. Sci. USA 89(6),2399-2403 (1992).
[2]. Melchini, A., and Traka, M.H. Biological profile of erucin: A new promising anticancer agent from cruciferous vegetables Toxins (Basel) 2(4),593-612 (2010).
[3]. Tarozzi, A., Morroni, F., Bolondi, C., et al. Neuroprotective effects of erucin against 6-hydroxydopamine-induced oxidative damage in a dopaminergic-like neuroblastoma cell line Int. J. Mol. Sci. 13(9),10899-10910 (2012).